Several countries in Europe, America, and Asia are notifying cases of monkeypox cases in people with no recent travel history to regions where the disease is endemic, that is, limited regions in Central and West Africa where the virus circulates. While the spread of the monkeypox virus in non-endemic countries is unusual and concerning, the cases detected so far are unlikely to cause a pandemic like SARS-CoV-2 did. The main reasons are that the number of cases is low, the virus doesn’t spread very easily, and smallpox vaccines also protect against monkeypox infection.