To date, more than 241 million people in the U.S. have received at least one dose of COVID-19 vaccine. Clinical trials as well as the safety monitoring of COVID-19 vaccination campaigns provide overwhelming evidence that the vaccines’ benefits far outweigh their risks. There’s no evidence indicating that the amount of spike protein generated by mRNA vaccination is dangerous. The use of multiple doses of COVID-19 vaccines isn’t unusual or unprecedented; some childhood vaccines that have been used for decades also require four or more doses for complete immunization.